Doctors Urged to Be Alert for Chikungunya Infection

Doctors Urged to Be Alert for Chikungunya Infection

PHILADELPHIA, PA -- July 6, 2007 -- Fever, arthritis, and other
symptoms occurring in people to who have recently traveled to islands
in the Indian Ocean may signal infection with an imported virus called
"chikungunya," reports a study in the May/June issue of the journal
Medicine®.



A group of French researchers report on the symptoms and outcomes of
chikungunya virus infection in 47 patients seen at the Leveran Hospital
in Marseilles. The lead author was Dr. Fabrice Simon, a specialist in
infectious and tropical diseases at the hospital.



All of the patients became ill during or shortly after travel to an
island in the Indian Ocean. Most were French tourists who had recently
visited Reunion or other Indian Ocean islands, while others were
residents of the islands who became ill while traveling in France.
Several cases occurred in people originally from the island of Comoros
-- there is a significant community of migrants from Comoros in
Marseilles.



During the acute phase of the infection, which lasted seven to ten
days, the main symptoms were fever and arthritis, most common in the
fingers, wrists, toes, and ankles. About half of the patients also had
a rash. Eight patients had to be hospitalized during the acute phase,
including two with life-threatening disease.



In 38 of the 47 patients, symptoms continued beyond the first 10 days.
This chronic phase of the infection was characterised by severe joint
pain and inflammation, which severely limited the patients' ability to
walk and perform everyday tasks. Some patients were so disabled that
hospitalization was required.



The chronic phase of the disease resolved very slowly -- over several
months. Treatment was solely symptomatic: pain-relievers and
anti-inflammatory drugs. Some patients improved with short-term steroid
treatment. Even after six months, nearly half of patients continued to
have symptoms. The infection was particularly painful and disabling for
some elderly patients.



Chikungunya virus is one of a group of viruses called arboviruses,
which includes West Nile virus. It comes from eastern Africa, where it
is spread by mosquitoes. (In the Makonde language of Tanzania and
Mozambique, "chikungunya" means "that which bends up" -- describing the
contorted posture caused by painful arthritis.)



Recently, Chikungunya virus has spread to Asia and India. In the past
two years there has been an "explosive outbreak" of Chikungunya virus
infection in the Indian Ocean islands—particularly on Reunion Island,
where 35 percent of a population of 770,000 became infected over a
6-month period. In 2006, the U.S. Centers for Disease Control issued a
warning about Chikungunya virus for people traveling to the Indian
Ocean islands, as well as to India and Sri Lanka. (Travelers looking
for the most recent updates can check the CDC's website: http://www.cdc.gov/travel/other/2006...unya_india.htm.)



The new report from France shows that this potentially serious
infection can easily be imported to Western countries by people who
travel to areas where outbreaks of Chikungunya virus -- sometimes
called "CHIKV" -- have occurred. As with other tropical diseases,
Western physicians may be unfamiliar with the symptoms and course of
the infection, which can lead to delays in making the correct
diagnosis. "Physicians should consider CHIKV when presented with a
patient with an unusual rheumatic syndrome after traveling to the
tropics," Dr. Simon and colleagues conclude.