medicalclub
Would you like to react to this message? Create an account in a few clicks or log in to continue.
medicalclub

medical college information and medical books
 
HomeHome  GalleryGallery  SearchSearch  Latest imagesLatest images  RegisterRegister  Log inLog in  

 

 Albuminuria and Risk of Nonvertebral Fractures

Go down 
AuthorMessage
obecalprx
moderator
obecalprx


Number of posts : 203
Location : nepal
Registration date : 2007-09-19

Albuminuria and Risk of Nonvertebral Fractures Empty
PostSubject: Albuminuria and Risk of Nonvertebral Fractures   Albuminuria and Risk of Nonvertebral Fractures Icon_minipostedFri Sep 21, 2007 12:12 am

Albuminuria and Risk of Nonvertebral Fractures



Lone Jørgensen, PhD; Trond Jenssen, MD, PhD; Luai Ahmed, MD, PhD;
Åshild Bjørnerem, MD; Ragnar Joakimsen, MD, PhD; Bjarne K. Jacobsen, PhD



Arch Intern Med. 2007;167:1379-1385.



Background Individuals with end-stage renal disease are at higher risk
of fractures compared with subjects in the general population. We
examined whether elevated albumin-creatinine ratios (ACRs) were
associated with nonvertebral fractures in subjects without diabetes or
macroalbuminuria.



Methods A total of 4497 subjects (2267 men and 2230 women) 55
to 74 years old at baseline were followed for a mean of 8.4 years.
Measurements of ACR, height, weight, blood pressure, lipids, serum
creatinine, and bone mineral density were performed, and information
about smoking and drinking habits, physical activity, prevalent
diseases, and use of medication was collected before the start of
follow-up. Nonvertebral fractures were registered during follow-up.



Results A total of 135 men and 382 women sustained a new
nonvertebral fracture. For a 1-SD higher value for the log-transformed
ACR, the relative risk for a fracture was 1.01 in men (P = .94, after
multiple adjustments) and 1.15 in women (P = .005). Women with ACRs in
the highest quartile had a 71% higher risk of nonvertebral fractures
compared with women with ACRs in the lowest quartile (P value for
linear trend over the quartiles, .001). Bone mineral density tended to
be lower with higher ACRs in both sexes, but this did not explain the
increased fracture risk in women.



Conclusion Albumin-creatinine ratio was associated with
nonvertebral fractures in women without diabetes or macroalbuminuria
but not in men.





Author Affiliations: Institutes of Community Medicine (Drs
Jørgensen, Ahmed, Bjørnerem, and Jacobsen) and Clinical Medicine (Drs
Jenssen and Joakimsen), University of Tromsø, Tromsø, Norway;
Departments of Physiotherapy (Dr Jørgensen) and Internal Medicine (Dr
Joakimsen), University Hospital of Tromsø; and Medical Department,
Division of Nephrology, Rikshospitalet, Oslo, Norway (Dr Jenssen).
Back to top Go down
 
Albuminuria and Risk of Nonvertebral Fractures
Back to top 
Page 1 of 1
 Similar topics
-
» Hydroxychloroquine and Risk of Diabetes in Patients With Rhe
» Estrogen Use Before 65 Linked to Reduced Risk of Alzheimer's
» Diabetics at Increased Risk of Hearing Loss: Presented at AD
» Ibuprofen May Boost Chance of Heart Problems in High Risk Pa
» New Test Helps Identify Hepatitis C Patients at High Risk of

Permissions in this forum:You cannot reply to topics in this forum
medicalclub :: E-books & Articles :: Latest Research And Medical News-
Jump to: